Microneedling with Rejuran 
Bakersfield, CA |
Monaco Aesthetics & Wellness

Some skin doesn't just need surface renewal — it needs to repair at a cellular level. Microneedling with Rejuran does exactly that. By pairing the FDA-cleared SkinPen® device with Rejuran's clinically proven polynucleotide (PDRN) technology, this treatment repairs the skin from within — restoring barrier function, reactivating collagen-producing cells, and rebuilding the structural foundation that healthy, resilient skin depends on.

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At Monaco Aesthetics & Wellness in Bakersfield, California, we turn to Rejuran when patients need more than rejuvenation — when they need genuine skin healing.

Whether you're dealing with early signs of aging, a compromised skin barrier, chronic dehydration, or skin that simply feels like it has lost its quality, Microneedling with Rejuran offers a deeply regenerative, natural-looking path forward.

What Is Microneedling with Rejuran?

Rejuran is a polynucleotide (PN/PDRN) skin booster developed in South Korea and widely recognized as one of the most effective skin healing treatments in aesthetic medicine. It is derived from highly purified salmon DNA — which shares a remarkable 97% biological similarity with human DNA — making it exceptionally biocompatible and well-tolerated by the body.

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PDRN (polydeoxyribonucleotide) works by increasing the metabolic activity of fibroblasts — the cells in the skin's dermis responsible for producing collagen, elastin, and glycosaminoglycans (the building blocks of the extracellular matrix). By stimulating these cells directly, Rejuran initiates a cascade of cellular repair that rebuilds skin structure, improves barrier function, and restores skin health over time.

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When combined with SkinPen® microneedling, Rejuran is infused directly through the micro-channels while the skin is at its most receptive. This allows the polynucleotides to penetrate deep into the dermis — delivering cellular repair signals far more effectively than any topical application could. The result is progressive, natural skin healing that continues to improve in the weeks following each treatment.

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At Monaco Aesthetics & Wellness in Bakersfield, CA, Microneedling with Rejuran is recommended for patients who want to address skin health at its source — not just the symptoms on the surface.

Microneedling with Rejuran effectively addresses:

• Weakened or compromised skin barrier

• Fine lines and early wrinkles

• Loss of skin elasticity and firmness

• Chronic dehydration and dullness

• Enlarged or congested pores

• Uneven skin texture and tone

• Post-inflammatory hyperpigmentation

• Sensitivity and general loss of skin quality

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Benefits of Microneedling with Rejuran

Rejuran addresses skin aging and skin damage from the inside out — working at a cellular level to rebuild what time, environment, and daily life break down. Unlike treatments that simply add volume or temporarily plump the skin, Rejuran's PDRN technology activates the skin's own repair processes, producing improvements that are genuine and lasting.

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Because it is derived from highly purified salmon DNA with 97% similarity to human DNA, Rejuran is exceptionally well-tolerated — even for patients with sensitive or reactive skin.

• Cellular-level skin repair via PDRN fibroblast activation

• Strengthened skin barrier and improved moisture retention

• Stimulates natural collagen and elastin production

• Reduces fine lines and early wrinkles progressively

• Improves skin elasticity, firmness, and bounce

• Restores skin hydration and reduces sensitivity

• Safe and highly biocompatible — derived from 97% human-DNA-similar salmon PDRN

• Suitable for all skin types including sensitive skin

• Minimal downtime — typically 1 to 3 days

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Who Is a Good Candidate for Microneedling with Rejuran?

Microneedling with Rejuran is ideal for patients who want to address the underlying quality of their skin — not just surface concerns. It's particularly well-suited to patients experiencing skin that feels thin, sensitive, reactive, or dehydrated, and those dealing with the early signs of structural aging.

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You may be an excellent candidate if you are:

• Noticing fine lines, early wrinkles, or loss of skin firmness and elasticity

• Dealing with a weakened skin barrier, sensitivity, or reactive skin

• Experiencing chronic dryness, dehydration, or dull complexion

• Looking for a natural, highly biocompatible skin healing treatment

• Wanting to improve overall skin quality, texture, and health

• Seeking a treatment appropriate for sensitive skin types

• Interested in preventative treatment to maintain long-term skin health

Microneedling with Rejuran is generally not recommended for patients who:

• Have active acne breakouts or skin infections in the treatment area

• Have a personal history of keloid or abnormal scarring

• Have a known allergy to fish or fish-derived products

• Are currently pregnant or breastfeeding

Your provider at Monaco Aesthetics & Wellness will review your skin and health history at your consultation to confirm this treatment is the right fit for you.

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What to Expect During Your Microneedling + Rejuran Treatment

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Before Your Appointment

Arrive with clean skin, free of makeup and active skincare products. Your provider may recommend pausing certain ingredients — such as retinoids or exfoliating acids — a few days prior to treatment. If you have a history of cold sores, let us know in advance.

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During Your Treatment

Your provider will cleanse your skin and apply a topical numbing cream. Once you are comfortable — typically after 20 to 30 minutes — the SkinPen® treatment is performed, creating thousands of controlled micro-channels across the treatment area. Rejuran is then applied and gently infused through those channels while the skin is most receptive. Most patients describe the sensation as mild pressure and a light vibrating feeling. Total appointment time is approximately 45 to 60 minutes.

After Your Treatment

Some mild redness, tightness, and warmth are normal immediately following treatment. Most patients experience:

• Days 1–3: Mild redness and skin sensitivity. Avoid makeup for the first 6–8 hours.

• Days 3–5: Possible light dryness or flaking as the skin renews.

• Days 7–10: Full resolution of visible side effects. Skin begins to look progressively smoother and more radiant.

Avoid saunas, intense exercise, and swimming pools for 5 days following treatment. Broad-spectrum SPF is essential — your skin will be more sensitive to UV during the healing phase.

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Microneedling + Rejuran Results

Results from Microneedling with Rejuran develop gradually and authentically — which is the hallmark of genuine cellular repair. Most patients notice improvements in skin hydration, texture, and overall quality within four to six weeks of their first session. With each treatment in a series, improvements compound as the skin continues to rebuild and repair.

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What patients typically experience over a full treatment series:

• Softer, smoother skin texture and refined pore appearance

• Improved skin elasticity and bounce

• Reduction in fine lines and early wrinkles

• Stronger, more resilient skin barrier

• Better moisture retention and reduced sensitivity

• A healthier, more luminous overall complexion

Most patients benefit from three to four treatments spaced four weeks apart for optimal results. Your provider will personalize this recommendation based on your skin condition and goals.

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Why Choose Monaco Aesthetics & Wellness for Microneedling + Rejuran in Bakersfield?

Rejuran is a treatment that requires both knowledge and expertise to deliver properly — and at Monaco Aesthetics & Wellness, our providers understand both the science behind it and the skill required to optimize results for each individual patient.

• FDA-cleared SkinPen® device — the foundation of every microneedling treatment we offer

• Clinically recognized PDRN technology — Rejuran is one of the most studied skin healing boosters available

• Highly biocompatible — derived from salmon DNA with 97% similarity to human DNA

• Personalized treatment protocols — depth and booster choice tailored to your specific skin concern

• Safety-first approach — trained providers with a deep understanding of skin anatomy

• Natural-looking results — progressive skin improvement that looks and feels authentic

• Luxury patient experience — attentive, personalized care from consultation to aftercare

Located at 9510 Flushing Quail Rd, Suite 122 in Bakersfield, CA — Monaco Aesthetics & Wellness is the Central Valley's trusted destination for advanced skin renewal.

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Microneedling + Rejuran FAQ

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What is PDRN and how does it work?

PDRN stands for polydeoxyribonucleotide — a type of polynucleotide derived from purified salmon DNA. It works by stimulating fibroblasts, the cells in your skin responsible for producing collagen, elastin, and the extracellular matrix. By activating these cells, PDRN initiates a cascade of skin repair and renewal at a cellular level.

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Is Microneedling with Rejuran painful?

Most patients tolerate this treatment very comfortably. A topical numbing cream is applied before the procedure to minimize sensation. During treatment, most patients feel mild pressure and a light buzzing feeling. Discomfort is uncommon.

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How long does the treatment take?

Total appointment time is approximately 45 to 60 minutes, including numbing time and the SkinPen® treatment.

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How many sessions will I need?

Most patients benefit from three to four sessions spaced four weeks apart for optimal results. Patients with milder concerns may see meaningful improvement in fewer sessions. Your provider will recommend a personalized plan at your consultation.

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Is Rejuran safe for sensitive skin?

Yes — Rejuran's high biocompatibility (97% similarity to human DNA) makes it exceptionally well-tolerated, even for patients with sensitive or reactive skin. It is one of the reasons we recommend Rejuran specifically for patients with compromised skin barrier or chronic sensitivity.

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When will I see results?

Initial improvements in skin hydration, texture, and quality are often visible within four to six weeks of the first session. Results continue to develop as the skin rebuilds — typically reaching their full expression eight to twelve weeks after completing a treatment series.

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Can Microneedling with Rejuran be combined with other treatments?

Yes. It pairs well with VI Peel, HydraFacial, CoolPeel, and Everesse laser. Your provider will advise on proper sequencing and timing to maximize results safely.

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Skin That Heals. Results That Last.

If your skin needs more than surface treatment — if it needs to genuinely repair, rebuild, and restore — Microneedling with Rejuran at Monaco Aesthetics & Wellness in Bakersfield, CA may be exactly what you've been looking for. We'll take the time to understand your skin, your concerns, and your goals, and build a plan designed to help you see real, lasting results.